Polimorfismos nos genes IL-2, IL-5, IL-8, IL-12 e IFN-y e a resposta a nematoides gastrintestinais em caprinos.
Polimorfismos nos genes IL-2, IL-5, IL-8, IL-12 e IFN-y e a resposta a nematoides gastrintestinais em caprinos.
Author(s): ZAROS, L. G.; SEABRA, L. M. S.; COUTINHO, L. L.; SILVA, F. C.; MEDEIROS, H. R. de; VIEIRA, L. da S.
Summary: Resumo: Cinco genes candidatos foram selecionados para identificar polimorfismos de nucleotídeo único e sua associação com a resposta de caprinos a nematoides gastrintestinais. Para isso, o DNA genômico dos animais mais resistentes e mais susceptíveis foi extraído e submetido ao sequenciamento de nova geração. Foram observados 71 SNPs, sendo 4 associados à resistência, o que os tornam alvos de estudos em toda a população de caprinos a fim de se confirmar essa associação. [Polymorphisms in IL-2, IL-5, IL-8, IL-12 e IFN-y genes and the response to gastrointestinal nematode in goats]. Abstract: Five candidate genes were selected to identify single nucleotide polymorphisms and its association with goat response to gastrointestinal nematodes. Genomic DNA from resistant and susceptible animals was extracted and submitted to new generation sequencing. It was observed 71 SNPs with 4 associated with resistance, which make them targets for studies on the entire population goats in order to confirm this association.
Publication year: 2015
Types of publication: Paper in annals and proceedings
Unit: Embrapa Goats & Sheep
Observation
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