Author(s): NUNES, A. A.; BUCCINI, D. F.; JAQUES, J. A. dos S.; PORTUGAL, L. C.; GUIMARÃES, R. C. A. da; FAVARO, S. P.; CALDAS, R. de A.; CARVALHO, C. M. E.

Summary: This study evaluated the effects of dietaries formulated with kernel oil of Acrocomia aculeata (AKO), rich in medium chain fatty acids (MCFA), as partial substitute of carbohydrate calories upon blood glucose, lipid profile, insulin secretion and insulin sensitivity in diabetic rats. Overall, the dietary with any AKO dose reduced hyperglycemia, ameliorated insulin secretion, lowered insulin resistance by model HOMA-IR and HOMA-Beta and augmented pancreatic beta cells functionality, restored the number of pancreatic Beta-cell in the diabetic rats and increased it in the non-diabetic rats. In addition, AKO fed rats showed reducing triglycerides, lower density lipoprotein-cholesterol and increasing high density lipoprotein-cholesterol levels, and improved hepatic function markers. Those findings suggest AKO was effective to ameliorate the health of diabetic rats.

Publication year: 2020

Types of publication: Journal article

Unit: Embrapa Agroenergy

Keywords: Cholesterol, Colesterol, Diabete, Diabetes mellitus, Diabetes tipo 2, Hiperglicemia, Hyperglycemia, Insulin resistance, Insulina, Macaúba, Nutracêuticos, Resistência à insulina, Ácido Lático, Ácido láurico