Antileishmanial and cytotoxic activity of dillapiole n-butyl ether.
Antileishmanial and cytotoxic activity of dillapiole n-butyl ether.
Author(s): BARROS, A. M. C.; PINTO, A. C. da S.; SIMPLICIO, F. G.; CHAVES, F. C. M.; SILVA, N. G. da; OLIVEIRA, K. M. T. de; LIMA, E. S.; FRANCO, A. M. R.
Summary: Abstract: Among the neglected diseases, American cutaneous leishmaniasis (ACL) still remains highly endemic in some tropical regions. The currently available drugs for treatment are highly toxic, prompting the search for new therapeutic options. The aim of this study was to evaluate the toxic potential of dillapiole n-butyl ether (DBE) against Leishmania amazonensis and L. guyanensis, as well as its toxicity on human peripheral blood mononuclear cells (PBMCs) in vitro. RESUMO: Dentre as doenças negligenciadas, a leishmaniose cutânea americana (LCA) continua sendo altamente endêmica em algumas regiões tropicais. Os medicamentos disponíveis atualmente para o tratamento apresentam elevada toxicidade, o que torna a busca de novas opções terapêuticas necessária. O objetivo do estudo foi avaliar o potencial tóxico do éter n-butil dilapiol (EBD) contra Leishmania amazonensis e L. guyanensis e a sua toxicidade em células mononucleares do sangue periférico humano (CMSP) in vitro.
Publication year: 2023
Types of publication: Journal article
Unit: Embrapa Western Amazon
Observation
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