Immunomodulatory and anticancer effects of Fridericia chica extract-loaded nanocapsules in myeloid leukemia.
Immunomodulatory and anticancer effects of Fridericia chica extract-loaded nanocapsules in myeloid leukemia.
Author(s): GOMES, A. de F.; BATALHA, A. D. de S. J.; ALVES, C. E. de C.; AZEVEDO, R. G. de; AMADO, J. R. R.; SOUZA, T. P. de; KOOLEN, H. H. F.; SILVA, F. M. A. da; CHAVES, F. C. M.; FLORENTINO NETO, S.; BOECHAT, A. L.; PONTES, G. S.
Summary: Nanocapsules provide selective delivery and increase the bioavailability of bioactive compounds. In this study, we examined the anticancer and immunomodulatory potential of Fridericia chica (crajiru) extract encapsulated in nanocapsules targeting myeloid leukemias. Nanocapsules containing crajiru (nanocapsules-CRJ) were prepared via interfacial polymer deposition and solvent displacement. Size and polydispersity were measured by dynamic light scattering. Biological assays were performed on leukemia cell lines HL60 and K562 and on non-cancerous Vero cells and human PBMC. The anticancer activity was evaluated using cytotoxicity and clonogenic assays, while the immunomodulatory activity was evaluated by measuring the levels of pro- and anti-inflammatory cytokines in PBMC supernatants treated with concentrations of nanocapsules-CRJ.
Publication year: 2024
Types of publication: Journal article
Unit: Embrapa Western Amazon
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