Resumo: Pharmaceuticals' biological effects can be enhanced via nanotechnology, resulting in decreased administered doses and deleterious effects. As a consequence, to prevent occidiosis in broiler poultry, toltrazuril-loaded polymeric nanoparticles based on poly-?-caprolactone (LNCt) were developed. The synthesized nanoformulations exhibited a consistent distribution of particle diameters within the nanometer range (z-mean and D (4.3) <200 nm), a negative zeta potential (<-8.93 mV), a drug content of approximately 100%, and an encapsulation efficiency exceeding 90%. Chickens were subsequently treated with LNCt for therapeutic purposes after being challenged with Eimeria oocysts. Assessment of the small intestine and cecum revealed that administration of LNCt (1.75 mg/kg/day) in potable water resulted in comparable reductions in oocyst excretion and lesion scores as the reference medication containing toltrazuril (7 mg/kg/day). In broilers, the current investigation demonstrates the potential efficacy of nanoencapsulated anticoccidial pharmaceuticals as a preventative measure against coccidiosis.

Ano de publicação: 2024

Tipo de publicação: Artigo em anais e proceedings

Unidade: Embrapa Suínos e Aves