Autoria: GUIMARÃES, R. P.; SANTOS, V. C.; PARANHOS, B. A. G.; AQUINO, N. C.; NASCIMENTO, R. R.; ALENCAR FILHO, E. B.

Resumo: Ceratitis capitata, known as Mediterranean fruit fly, represents one of the main problems to the agricultural production, due the ability to infest a wide variety of fruits, which makes it one of the most worrying pests globally. The infestation of host fruits by the insect compromises their quality and appearance, causing losses to their commercialization and consumption. In order to minimize this problem, fruit growers have adopted the indiscriminate use of conventional insecticides that raise environmental and public health concerns, in addition to promoting resistance in insects. Alternatively, semiochemicals have been explored as a management tool, attracting males and females into traps or promoting repellency in exposed fruits. In this context, in silico approaches, as Molecular Docking, Molecular Dynamics and the Virtual Screening procedures, offer opportunities to identify new molecular entities as potential ligands to Odorant Binding Proteins (OBP), that are involved in olfactory communication of C. capitata. In this review, we present a collection of data including the chemistry of olfactory communication of C. capitata and some computational tools that can be used in these studies, emphasizing their impact on the behavior of this and other associated insects. We also address theoretical ADME-Tox parameters as initial evaluation criteria to ensure human safety in the environmental applications, as well as the importance of molecular synergism for the effective management of the medfly.

Ano de publicação: 2025

Tipo de publicação: Artigo de periódico

Unidade: Embrapa Semiárido

Palavras-chave: Biological control, Ceratitis Capitata, Ciclo de Vida, Controle Biológico, Fruit flies, Importância econômica, Insects, Inseto, Mosca das Frutas, Mosca do Mediterrâneo, Praga, Produção Agrícola