Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.
Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.
Author(s): RODRIGUES, I. A.; AZEVEDO, M. M. B.; CHAVES, F. C. M.; ALVINO, C. S.; ALVIANO, D. S.; VERMELHO, A. B.
Summary: Currently available leishmaniasis treatments are limited due to severe side effects. Arrabidaea chica is a medicinal plant used in Brazil against several diseases. In this study, we investigated the effects of 5 fractions obtained from the crude hexanic extract of A. chica against Leishmania amazonensis and L. infantum, as well as on the interaction of these parasites with host cells. Promastigotes were treated with several concentrations of the fractions obtained from A. chica for determination of their minimum inhibitory concentration (MIC).
Publication year: 2014
Types of publication: Journal article
Unit: Embrapa Western Amazon
Keywords: Arrabidaea chica, Crajiru
Observation
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