Estimation of linkage disequilibrium, persistence of phase and effective population size of Brazilian Hereford and Braford breeds.
Estimation of linkage disequilibrium, persistence of phase and effective population size of Brazilian Hereford and Braford breeds.
Author(s): BIEGELMEYER, P.; OLIVEIRA, M. M.; CARDOSO, L. L.; GULIAS-GOMES, C. C.; HIGA, R. H.; DIONELLO, N. J. L.; CAETANO, A. R.; STEIBEL, J. P.; CARDOSO, F. F.
Summary: A set of 41,241 SNP genotypes from 2,435 Hereford (HH) and Braford (BO) bovines were analyzed to estimate linkage disequilibrium (LD) levels, persistence of phase and effective population size of these populations. LD levels were estimated using the squared correlation of alleles at two loci (r2) at varying distances. Average r2 between adjacent SNP was 0.21 for HH and 0.16 for BO. Average inter-marker distance was 61 kb in both breeds. Useful LD values (r2>0.2) were observed at 0-60 kb bins in HH and 0-20 kb bins in BO. Breeds demonstrated moderate to strong persistence of phase at all distances (range=0.53- 0.97). The greatest phase correlations (r>0.9) were found in 0-50 kb bins. LD estimates decreased rapidly with increasing distances between SNPs, however, useful LD was observed in genomic regions spanning up to ~50 kb.
Publication year: 2014
Types of publication: Paper in annals and proceedings
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