Pig respiratory infections caused by influenza A viruses (FLUAVs) lead to significant economic losses and pose a threat to human health due to the possibility of pandemics. Although Brazil has one of the largest world's pig herds (41 million animals), there was little evidence of FLUAVs' presence in Brazilian pig herds before 2009. After detecting the H1N1 pandemic virus (H1N1/2009) in 2009, influenza surveillance efforts in Brazilian pig production increased. Consequently, new influenza viruses began to be detected. This project aims to study the genetic and antigenic evolution of influenza viruses in pigs raised in Brazil, propose alternatives for rapid diagnosis and disease control using a nanotechnological vaccine, and investigate the pathogen-host interaction. This project's development will count on the partnership of other research institutions and national and international universities. This joint work will allow the application of a multidisciplinary action strategy, in which basic virology, immunology, bioinformatics, and genetics and genomics methodologies will be integrated. It is expected to expand knowledge about the genetic and antigenic diversity of FLUAVs circulating in pigs in Brazil, develop new diagnostic inputs, validate a new vaccine strategy for controlling the disease in pigs, and evaluate biosecurity measures on farms. The project will also contribute to deepening the knowledge of genetic mechanisms related to immune responses of vaccination against FLUAV, allowing a better understanding of the pathways already described and also enabling the discovery of new genetic mechanisms related to immune responses.