As a World Health Organization and Codex Alimentarius member, Brazil needs to respond to global calls to improve human health and food production. At the heart of this debate is the interdisciplinary challenge of controlling resistance to antimicrobials. In addition to measures aimed at those focusing on human health, advances are also needed in the agricultural sector, both in knowledge and in immediate measures for rational use of antimicrobials and control of resistance spread. In this sense, Brazil has implemented the Prevention and Control of Antimicrobial Resistance National Action Plan (PAN-BR), cooperation between the ministries of Health and Agriculture, Livestock, and Supply. The specific actions of the agricultural sector are described in PAN-BR Agro. One of the plan's objectives is to "strengthen knowledge and scientific base through surveillance and research" so that Brazil can improve the control of antimicrobial resistance from a unique health perspective. An interdisciplinary research team from Embrapa Swine and Poultry and universities, in collaboration with the Veterinary Medicines General Coordination of the Ministry of Agriculture, prepared this proposal that addresses the following priority themes: 1) economic impacts and cost-effectiveness assessment of antimicrobials usage practices; 2) impacts of manure management systems on the persistence of resistance to antimicrobials; and 3) manure management to reduce antimicrobial resistance spreading risks. These themes were organized into two contributions to innovation: 1) economic impact of best production practices that influence antimicrobials usage in intensive pig production; and 2) evaluating the persistence of resistance determinants to antimicrobials in pig farms. The proposal's general objective is to subsidize PAN-BR Agro with economic and environmental studies of agricultural practices that impact antimicrobials usage in intensive pig production and the persistence of resistant determinants to antimicrobials in the environment.