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Author(s): CERDEIRA, A. L.; QUEIROZ, S. C. do N. de; MATALLO, M. B.

Resumo: Oseltamivir phosphate (OSP), marketed under the brand name of Tamiflu®, is a potent inhibitor of viral neuraminidase, a glycoside hydrolase enzyme essential for viral replication. OSP is also... ...

Repository: BDPA     Publication year: 2020

Author(s): ALMEIDA, S. D. B. de; FRANCO, D. A. de S.; CERDEIRA, A. L.; QUEIROZ, S. C. do N. de; MATALLO, M. B.

Abstract: Shikimic acid (SA) has witnessed a strong increase in recent years due to the increasing demand of the pharmaceutical and cosmetic industry. The SA is used as a precursor for the synthesis o... ...

Repository: BDPA     Publication year: 2020

Author(s): MATALLO, M. B.; ALMEIDA, S. D. B.; FRANCO, D. A. S.; CERDEIRA, A. L.; GAZZIERO, D. L. P.

Resumo: O fosfato de oseltamivir, ingrediente ativo do antiviral Tamiflu®, é um potente inibidor viral produzido a partir do ácido chiquímico e extraído da semente de Ilicium verum, sua mais important... ...

Repository: BDPA     Publication year: 2014

Author(s): COSTA, M. C. A.; MATALLO, M. B.; FERREIRA, M. M. C.; QUEIROZ, S. C. do N. de; ALMEIDA, S. D. B.; FRANCO, D. A. S.

Shikimic acid is a natural compound, precursor of the antiviral Oseltamivir used against influenza A. It is a scarce and expensive chemical, obtained mainly from seeds of shrubs natives in China and J... ...

Repository: BDPA     Publication year: 2016

Author(s): MATALLO, M. B.; ALMEIDA, S. D. B.; FRANCO, D. A. S.; CERDEIRA, A. L.; GAZZIERO, D. L. P.

ABSTRACT - Oseltamivir phosphate is a potent viral inhibitor produced from shikimic acid extracted from seeds of Ilicium verum, the most important natural source. With the site of action 5-enolpyruvyl... ...

Repository: BDPA     Publication year: 2014

Author(s): FRANCO, D. A. S.; ALMEIDA, S. D. B.; MOURA, M. A. M.; BOTTEON, J. E.; CERDEIRA, A. L.; QUEIROZ, S. C. do N. de; MATALLO, M. B.

Resumo: Periodicamente a humanidade é assolada por pandemias de gripe com consequências fatais. Dessa forma, o desenvolvimento de medidas eficazes para combater as viroses é de crucial importância par... ...

Repository: BDPA     Publication year: 2014

Author(s): MATALLO, M. B.; ALMEIDA, S. D. B.; CERDEIRA, A. L.; FRANCO, D. A. S.; BLANCO, F. M. G.; MENEZES, P. T. C.; LUCHINI, L. C.; MOURA, M. A.; DUKE, S. O.

A better method for determination of shikimate in plant tissues is needed to monitor exposure of plants to the herbicide glyphosate [N-(phosphonomethyl)glycine] and to screen the plant kingdom for hig... ...

Repository: BDPA     Publication year: 2009

Author(s): COSTA, M. C. A.; MATALLO, M. B.; FERREIRA, M. M. C.; QUEIROZ, S. C. do N. de; ALMEIDA, S. D. B.; FRANCO, D. A. S.

Abstract: Shikimic acid is a natural organic compound produced in the biochemical pathways of eukaryotic organisms and is generally utilized as a starting material of the antiviral drug Oseltamivir (T... ...

Repository: BDPA     Publication year: 2016

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