The technology for gene editing based on the CRISPR / Cas9 system (Clustered Regularly-Interspaced Short Palindromic Repeats associated to Cas9 endonuclease) consists of an endonuclease (Cas9) guided by RNA (guide RNA - sgRNA), which is capable of editing the genome with accuracy. This system enables the inactivation of genes through cleavage followed by repairing the strands by non-homologous end joining (NHEJ) leading to the knockout of the expression, which results extremely useful to prevent

Status: Completed     Start date: 01/01/2018